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PET/MR Imaging in Head and Neck Cancer
Head and neck squamous cell carcinoma (HNSCC) can either be examined with hybrid PET/MR imaging systems or sequentially, using PET/CT and MR imaging. Regardless of the acquisition technique, the superiority of MR imaging compared to CT lies in its potential to interrogate tumor and surrounding tissues with different sequences, including perfusion and diffusion. For this reason, PET/MR imaging is preferable for the detection and assessment of locoregional residual/recurrent HNSCC after therapy. In addition, MR imaging interpretation is facilitated when combined with PET. Nevertheless, distant metastases and distant second p...
Source: Magnetic Resonance Imaging Clinics of North America - September 22, 2023 Category: Radiology Authors: Minerva Becker, Claudio de Vito, Nicolas Dulguerov, Habib Zaidi Source Type: research
BBB opening by low pulsed electric fields, depicted by delayed-contrast MRI, enables efficient delivery of therapeutic doxorubicin doses into mice brains
ConclusionsOur results demonstrate significant BBBo levels induced by extra-cranial L-PEFs, enabling efficient delivery of therapeutic Doxo doses into the brain and reducing tumor growth. As BBBo was undetectable by standard contrast-enhanced MRI, DCM was applied to generate maps depicting the BBBo levels throughout the brain. These findings suggest that BDF is a promising technology for efficient drug delivery into the brain with important implications for future treatment of brain cancer and additional CNS diseases.
Source: Fluids and Barriers of the CNS - September 22, 2023 Category: Neuroscience Source Type: research
Does heparin rebound lead to postoperative blood loss in patients undergoing cardiac surgery with cardiopulmonary bypass?
CONCLUSION: The influence of heparin rebound on postoperative bleeding seems to be negligible, but might get significant in conjunction with incomplete heparin reversal or other coagulopathies. For that reason, it might be useful to get a picture of the entire coagulation spectrum after cardiac surgery, as can be done by the use of a viscoelastic test in conjunction with an aggregometry test.PMID:37734336 | DOI:10.1177/02676591231199218
Source: Perfusion - September 21, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Marije Rijpkema Eline A Vlot Marco C Stehouwer Peter Bruins Source Type: research
Role of toll-like receptor-mediated pyroptosis in sepsis-induced cardiomyopathy
Biomed Pharmacother. 2023 Sep 19;167:115493. doi: 10.1016/j.biopha.2023.115493. Online ahead of print.ABSTRACTSepsis, a life-threatening dysregulated status of the host response to infection, can cause multiorgan dysfunction and mortality. Sepsis places a heavy burden on the cardiovascular system due to the pathological imbalance of hyperinflammation and immune suppression. Myocardial injury and cardiac dysfunction caused by the aberrant host responses to pathogens can lead to cardiomyopathy, one of the most critical complications of sepsis. However, many questions about the specific mechanisms and characteristics of this ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Yixuan Fan Baoyi Guan Jianxing Xu He Zhang Liang Yi Zhixu Yang Source Type: research
Multiscale Structure and Function of the Aortic Valve Apparatus
Physiol Rev. 2023 Sep 21. doi: 10.1152/physrev.00038.2022. Online ahead of print.ABSTRACTWhile studying the aortic valve in isolation has facilitated the development of life-saving procedures and technologies, the dynamic interplay of the aortic valve and its surrounding structures is vital to preserving their function across the wide range of conditions encountered in an active lifestyle. Our view is that these structures should be viewed as an integrated functional unit, herein referred to as the aortic valve apparatus (AVA). The coupling of the aortic valve and root, left ventricular outflow tract, and blood circulation...
Source: Physiological Reviews - September 21, 2023 Category: Physiology Authors: Hussam El-Nashar Malak Sabry Yuan-Tsan Tseng Nadine Francis Najma Latif Kim H Parker James E Moore Magdi H Yacoub Source Type: research
Microvascular dysfunction in women with a history of hypertensive disorders of pregnancy: A population-based retrospective cohort study
CONCLUSIONS: The findings reveal microvascular dysfunction at long-term follow up in women with previous pre-eclampsia and strengthen the possible role of endothelial dysfunction as a link to the increased risk of cardiovascular disease in women with HDP.PMID:37732494 | DOI:10.1111/1471-0528.17665
Source: BJOG : An International Journal of Obstetrics and Gynaecology - September 21, 2023 Category: OBGYN Authors: Stina Bj örkman Caroline Lilliecreutz Marie Bladh Tomas Str ömberg Carl Johan Östgren Arina Mahmoud Arian Kafashian Sara Bergstrand Sofia Sederholm Lawesson Source Type: research
Effect of cerebral oxygen saturation monitoring in patients undergoing superficial temporal anterior-middle cerebral artery anastomosis for ischemic Moyamoya disease: a prospective cohort study
ConclusionPerioperative rSO2 surveillance enhanced cerebral perfusion and minimized postoperative complications in ischemic MMD patients. Thus, rSO2 monitoring is advocated for MMD patients undergoing vascular anastomosis.
Source: Frontiers in Neurology - September 21, 2023 Category: Neurology Source Type: research
Dapagliflozin promotes angiogenesis in hindlimb ischemia mice by inducing M2 macrophage polarization
Critical limb ischemia (CLI) is associated with a higher risk of limb amputation and cardiovascular death. Dapagliflozin has shown great potential in the treatment of cardiovascular disease. However, the effects of dapagliflozin on CLI and the underlying mechanisms have not been fully elucidated. We evaluated the effect of dapagliflozin on recovery from limb ischemia using a mouse model of hindlimb ischemia. The flow of perfusion was evaluated using a laser Doppler system. Tissue response was assessed by analyzing capillary density, arterial density, and the degree of fibrosis in the gastrocnemius muscle. Immunofluorescenc...
Source: Frontiers in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Source Type: research
Can Open Distal Repair Be Safely Used in All Patients with Type A Acute Aortic Dissection?
CONCLUSION: We conclude that the open repair can be used in most if not all cases of surgical repair of type A acute aortic dissection.PMID:37730310 | DOI:10.5761/atcs.oa.23-00086
Source: Annals of Thoracic and Cardiovascular Surgery - September 20, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Georgi Manchev Vassil Gegouskov Vladimir Kornovski Georgi Yankov Valya Goranovska Vicktoria Ilieva Vicktoria Petrova Source Type: research
Hyperpolarized 1- < sup > 13 < /sup > Cpyruvate Magnetic Resonance Spectroscopy Shows That Agmatine Increased Lactate Production in the Brain of Type 2 Diabetic Mice
CONCLUSION: Agmatine influences the NADH/NAD+ redox state in the brains of T2DM mice, which may be connected with enhanced cognitive performance and increased conversion of HP [1-13C]pyruvate to HP [1-13C]lactate.PMID:37727922 | DOI:10.3349/ymj.2022.0554
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: Young-Suk Choi Jae Eun Song Eosu Kim Chul Hoon Kim Jong Eun Lee Ho-Taek Song Source Type: research
Can Open Distal Repair Be Safely Used in All Patients with Type A Acute Aortic Dissection?
CONCLUSION: We conclude that the open repair can be used in most if not all cases of surgical repair of type A acute aortic dissection.PMID:37730310 | DOI:10.5761/atcs.oa.23-00086
Source: Annals of Thoracic and Cardiovascular Surgery - September 20, 2023 Category: Cardiovascular & Thoracic Surgery Authors: Georgi Manchev Vassil Gegouskov Vladimir Kornovski Georgi Yankov Valya Goranovska Vicktoria Ilieva Vicktoria Petrova Source Type: research
Prediction of adenocarcinoma and squamous carcinoma based on CT perfusion parameters of brain metastases from lung cancer: a pilot study
ConclusionCT perfusion parameter analysis of brain metastases in patients with primary lung cancer could be used to classify adenocarcinoma and squamous carcinoma.
Source: Frontiers in Oncology - September 20, 2023 Category: Cancer & Oncology Source Type: research
Human umbilical cord mesenchymal stem cell-derived extracellular vesicles loaded with TFCP2 activate Wnt/ β-catenin signaling to alleviate preeclampsia
CONCLUSION: From our data we conclude that hUCMSCs-EVs overexpressing TFCP2 may be instrumental for the therapeutic targeting and clinical management of PE.PMID:37724958 | DOI:10.1016/j.intimp.2023.109732
Source: International Immunopharmacology - September 19, 2023 Category: Allergy & Immunology Authors: Zhongmei Yang Xiaoyan Jia Qinyin Deng Mengdie Luo Yan Hou Jun Yue Jie Mei Nan Shan Zhao Wu Source Type: research
Three-dimensional electrical impedance tomography (EIT) to study regional ventilation/perfusion (V/Q ̇) ratios in anesthetized pigs
This study aimed to develop a 3D method for assessing ventilation/perfusion (V/Q̇) ratios in a pig model of hemodynamic perturbations using electrical impedance tomography (EIT). In order to evaluate the physiological coherence of changes in EIT-derived V/Q̇ ratios, global EIT-derived V/Q̇ mismatches were compared with global gold-standards. The study found regional heterogeneity in the distribution of V/Q̇ ratios in both the ventrodorsal and craniocaudal directions. Although global EIT-derived indices of V/Q̇ mismatch consistently underestimated both low and high V/Q̇ mismatch compared to global gold standards, the ...
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - September 19, 2023 Category: Cytology Authors: Shannon Larrabee Sarah Nugen Alejandro Bruhn Ian Porter Symon Stowe Andy Adler Manuel Martin-Flores Joaquin Araos Source Type: research
